Peer Review Request - Decline Confirmation

BMS-CAR-2024-297


Article Title:
CSF Growth Associated Protein-43 and Brain atrophy in Mild Cognitive Impairment: A cross sectional and longitudinal study
Abstract:
BACKGROUND: To diagnose and treat Alzheimer's disease (AD) in its initial stages is the main goal of recent AD studies. Cerebrospinal fluid growth associated protein (GAP)-43 has been proposed as a potential biomarker for AD and an indicator of synaptic degeneration. OBJECTIVE: We aimed to find out whether CSF GAP-43 is associated with brain atrophy and if it differs between mild cognitive impairment and cognitive normal subjects. METHODS: We examined 22 cognitive normal subjects and 29 mild cognitive impairment subjects enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We evaluated subjects brain atrophy rates using tensor-based morphometry-symmetric diffeomorphic image normalization method (TBM-SyN) which demonstrates annual brain atrophy rates and CSF GAP-43 levels. Data were analyzed in three time points: baseline, 24 and 48 month follow up. RESULTS: TBM scores and GAP-43 levels did not differ significantly between the CN and MCI groups at any time point. However, significant changes in TBM scores were observed over time in both groups. A significant negative correlation between TBM scores and GAP-43 levels was found in the CN group at baseline and at 48 months but this correlation was not present in the MCI group. Mixed-effects models revealed significant associations between time points and TBM scores, with no significant interaction involving GAP-43. CONCLUSIONS: GAP-43 levels correlate with TBM scores in CN individuals but not in those with MCI. Further studies are needed to validate its role in tracking cognitive decline in MCI.

Reason for Declining the Review Request:






If you wish to recommend anyone who could review this manuscript, then please provide the details as follows:

  Suggested Reviewer's Contact Details: